Prediction Guard vs Prisma AIRS

Prediction Guard sells a self-hosted "sovereign AI control plane" for regulated organizations. It sits between applications and the models, agents and MCP tools they call, and applies access, safety and policy controls to each request inside the customer's own infrastructure. The company was founded in 2023 in Lafayette, Indiana; CEO Daniel Whitenack is a co-founder. It raised a $3.7 million seed round led by Sovereign Capital in May 2025, and Noblis Ventures made a strategic investment of undisclosed size in July 2025. At the time of the seed round it had eight employees and said it had 18 customers in health care, defense, transportation and manufacturing. The platform registers each agent with an identity and role and limits it to the models and tools that role needs. Runtime controls include PII masking, prompt injection detection, toxicity filtering, input sanitization, MCP tool scoping and human-in-the-loop approval; requests that fail a policy are blocked and logged. It produces an exportable AI bill of materials (CycloneDX) of models, guardrails and MCP servers, runs model security scans and streams security events to SIEM tools such as Splunk, Datadog and Grafana. Applications call it through OpenAI- and Anthropic-compatible APIs. It deploys into a customer VPC on AWS, Azure or Google Cloud, on Kubernetes on premises, or air-gapped. Prediction Guard says its control overhead is under 200 ms per request. **AI compliance coverage** Prediction Guard says its policies align with the NIST AI RMF, NIST AI 600-1, the OWASP Top 10 for LLM and agentic applications, OMB M-26-04 and AIUC-1, with one-click baselines and an exportable "proof of alignment" for the NIST AI RMF. A company blog post (August 2026) adds the EU AI Act and ISO/IEC 42001. The same post labels its OWASP mapping "self-published" and not independently verified, and notes that the audit log records enforcement events rather than full replayable traces. We found no published control-by-control mapping. The homepage shows badges for a SOC 2 Type 2 report by Sensiba and HIPAA compliance; there is no public trust center. **Who it's for** Regulated enterprises and public sector bodies that want AI guardrails and agent controls to run inside their own network, including disconnected environments. It is sold to government through Carahsoft. Its homepage quotes executives at Noblis (also an investor), SimWerx and iBase-t.

Prisma AIRS is Palo Alto Networks' platform for securing AI applications, agents, models and data. Palo Alto Networks launched it on April 28, 2025, the same day it announced its intent to acquire Protect AI, a Seattle AI security company, and completed that acquisition on July 22, 2025. Prisma AIRS 2.0, released October 28, 2025, "completes the native integration" of Protect AI, and Protect AI's chief executive, Ian Swanson, joined as VP, Product, Prisma AIRS. The protectai.com site now redirects to the Prisma AIRS page, and the README of Protect AI's open-source LLM Guard library says the project has been archived. Palo Alto Networks was incorporated in 2005 and is based in Santa Clara; this profile lists the company's founding year and headquarters, as the directory does for other big-company products. Palo Alto's fiscal 2026 annual report lists six parts: AI Gateway, Agent Security, AI Red Teaming, AI Runtime Security, AI Model Security (labeled AI Supply Chain Security on the current product page) and AI Posture Management. AI Runtime Security comes in two forms. API Intercept is called from application code through a REST API to scan prompts and model responses. Network Intercept inspects cloud network traffic inline and is managed from Strata Cloud Manager or Panorama. The platform supports AWS, Azure, Google Cloud, Kubernetes, private clouds and on-premises infrastructure. AI Red Teaming tests agentic and non-agentic systems with a library of more than 500 attack vectors across 50+ techniques and produces a risk score. AI Model Security scans models for tampering, malicious code, data poisoning, architectural backdoors and unsafe serialization formats. **Agent security** The product page now adds Agent Identity Security and Agentic Endpoint Security. Palo Alto completed its acquisition of Koi, which adds agentic endpoint security, in April 2026. On May 29, 2026 it completed its acquisition of Portkey, whose gateway becomes the core AI Gateway for Prisma AIRS: it routes, monitors and secures traffic between agents and models. **Frameworks** Palo Alto maps AI Red Teaming attacks to the OWASP Top 10 for LLMs, MITRE ATLAS and what it calls the NIST Risk Management Framework. We found no documented support for the EU AI Act or ISO 42001. **Who it's for** Enterprises, especially existing Palo Alto Networks customers on Strata Cloud Manager, that want model scanning, red teaming and runtime protection funded from the same credit pool as their software firewalls.