CalypsoAI vs Prisma AIRS

CalypsoAI was an AI security company founded in the US in 2018 by Neil Serebryany, its first CEO; it describes itself as founded in Silicon Valley, and its early press releases carry Washington datelines. It began with software for testing, validating and monitoring AI and machine learning models for national security, finance and other regulated customers, and moved to securing generative AI with CalypsoAI Moderator in 2023. Donnchadh Casey became CEO in August 2024. In October 2024 CalypsoAI named Dublin its global co-headquarters, alongside a US headquarters in New York; IDA Ireland says the CEO, the CTO and most of its R&D were based in Dublin. Paladin Capital Group led its $13 million Series A (July 2020) and a $23 million Series A-1 (June 2023), and F5 says it raised more than $40 million in venture funding. Investors also included Lockheed Martin Ventures and Hakluyt Capital. F5 announced on September 11, 2025 that it would acquire CalypsoAI for $180 million in purchase consideration, mostly cash. F5's 10-Q says the deal closed on September 26, 2025 and records $145.2 million in cash consideration. CalypsoAI is no longer sold separately: calypsoai.com now redirects to F5's AI Guardrails page. F5 introduced F5 AI Guardrails and F5 AI Red Team when it announced the close, and made both generally available in January 2026. Buyers should evaluate those products. **What it sold** By 2025 CalypsoAI sold an inference security platform with two main products. Inference Defend checked prompts and responses in real time to block prompt injection, jailbreaks and sensitive data leakage, using custom scanners that could be versioned, tested and enforced per project. Inference Red-Team ran automated and agent-driven multi-turn attacks, drawing on more than 10,000 new attack prompts a month, and produced a risk score. The platform logged AI interactions for audit, sent logs to Splunk, and ran as SaaS, on premises or hybrid. In August 2025 CalypsoAI said an on-premises version of Red-Team, for organizations with strict data residency or air-gapped requirements, would soon be available in early access. **Frameworks** In August 2025 CalypsoAI added an EU AI Act scanner package to Inference Defend, covering four Article 5 prohibited-practice categories: manipulation, social scoring, biometric data harvesting and surveillance. F5's deal announcement said its governance features help customers meet GDPR and EU AI Act requirements. We found no CalypsoAI mapping to the NIST AI RMF or ISO 42001.

Prisma AIRS is Palo Alto Networks' platform for securing AI applications, agents, models and data. Palo Alto Networks launched it on April 28, 2025, the same day it announced its intent to acquire Protect AI, a Seattle AI security company, and completed that acquisition on July 22, 2025. Prisma AIRS 2.0, released October 28, 2025, "completes the native integration" of Protect AI, and Protect AI's chief executive, Ian Swanson, joined as VP, Product, Prisma AIRS. The protectai.com site now redirects to the Prisma AIRS page, and the README of Protect AI's open-source LLM Guard library says the project has been archived. Palo Alto Networks was incorporated in 2005 and is based in Santa Clara; this profile lists the company's founding year and headquarters, as the directory does for other big-company products. Palo Alto's fiscal 2026 annual report lists six parts: AI Gateway, Agent Security, AI Red Teaming, AI Runtime Security, AI Model Security (labeled AI Supply Chain Security on the current product page) and AI Posture Management. AI Runtime Security comes in two forms. API Intercept is called from application code through a REST API to scan prompts and model responses. Network Intercept inspects cloud network traffic inline and is managed from Strata Cloud Manager or Panorama. The platform supports AWS, Azure, Google Cloud, Kubernetes, private clouds and on-premises infrastructure. AI Red Teaming tests agentic and non-agentic systems with a library of more than 500 attack vectors across 50+ techniques and produces a risk score. AI Model Security scans models for tampering, malicious code, data poisoning, architectural backdoors and unsafe serialization formats. **Agent security** The product page now adds Agent Identity Security and Agentic Endpoint Security. Palo Alto completed its acquisition of Koi, which adds agentic endpoint security, in April 2026. On May 29, 2026 it completed its acquisition of Portkey, whose gateway becomes the core AI Gateway for Prisma AIRS: it routes, monitors and secures traffic between agents and models. **Frameworks** Palo Alto maps AI Red Teaming attacks to the OWASP Top 10 for LLMs, MITRE ATLAS and what it calls the NIST Risk Management Framework. We found no documented support for the EU AI Act or ISO 42001. **Who it's for** Enterprises, especially existing Palo Alto Networks customers on Strata Cloud Manager, that want model scanning, red teaming and runtime protection funded from the same credit pool as their software firewalls.